Category Archives: CAM Interactions

Pomegranate juice doesn’t inhibit cytochrome P450 enzymes in humans

Several years ago a study in human liver tissue and in rats concluded that pomegranate juice inhibited CYP3A — a liver enzyme in the cytochrome P450 system important for metabolizing drugs. The implications were that — just as with grapefruit — people taking drugs such as statins for cholesterol might be exposed to much higher blood levels and greater risk of side effects.

We now find that when studied in healthy volunteers, pomegranate juice is not associated with this risk.

Continue reading Pomegranate juice doesn’t inhibit cytochrome P450 enzymes in humans →

Transplant patients are cautioned about taking Schisandra

Schisandra sphenanthera (Nan Wu Wei Zi, lemon-wood) is “commonly used in Chinese herbalism, where it is considered to be one of the 50 fundamental herbs.” I found no clinical study in humans to support the many claims for this Chinese herbal medicine.

Now, there’s a report of a drug interaction with tacrolimus (Prograf) — a drug used to suppress the immune system in order to prevent organ rejection of liver, kidney, or heart transplants. Continue reading Transplant patients are cautioned about taking Schisandra →

A major review of omega 3 fatty acids

Over 3 decades, the potential health benefits of omega-3 polyunsaturated fatty acids have been studied, debated, and explained.

If you’ve been looking for a single authoritative and well-documented source on this subject, look no further than this article in the Journal of Nurse Practitioners on Medscape. Continue reading A major review of omega 3 fatty acids →

Herbal interactions with immunosuppressive drugs

Dr. James Beaulieu, a clinical pharmacist specialist at Rhode Island Hospital in Providence, has published an excellent review of this topic.

If you are receiving immunosuppressive treatments and taking or considering taking any herbal medicine, consult this article first.

Immunosuppressive therapy is used for the following reasons.

  • Prevent rejection of transplanted organs and tissues (eg, bone marrow, heart, kidney, liver)
  • Treat autoimmune diseases or diseases that are most likely of autoimmune origin (eg, rheumatoid arthritis, myasthenia gravis, systemic lupus erythematosus, Crohn’s disease, and ulcerative colitis)

A list and overview of immunosuppressive drugs are available here.

9/24/06 11:18 JR