The C.A.M. Report
Complementary and Alternative Medicine: Fair, Balanced, and to the Point
  • About this web log

    This blog ran from 2006 to 2016 and was intended as an objective and dispassionate source of information on the latest CAM research. Since my background is in pharmacy and allopathic medicine, I view all CAM as advancing through the development pipeline to eventually become integrated into mainstream medical practice. Some will succeed while others fail. But all are treated fairly here.

  • About the author

    John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at, a complementary and alternative medicine website.

  • Common sense considerations

    The material on this weblog is for informational purposes. It is not medical advice or counsel. Be smart, consult your health professional before using CAM.

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    Long-term response to soy isoflavones

    Researchers at the University of California, Davis, studied the response to soy hypocotyl isoflavone supplementation in healthy menopausal women.

    In the plant seed, the hypocotyl connects the embryonic root to the seed leaf.

    First, the details.

    • 403 postmenopausal women were assigned to a treatment group for 24 months.
      • 80 or 120 mg aglycone equivalent soy hypocotyl isoflavones + calcium and vitamin D daily
      • Placebo
    • Blood chemistry values were measured and a well-woman examination was conducted, which included a mammogram and a Papanicolaou (PAP) test.
    • The presence of endometrial thickening and fibroids were evaluated.
    • Neither the patients nor researchers knew the treatment given — double blind.

    And, the results.

    • The groups were similar at the start of the study.
    • After 2 years of taking daily isoflavone, all clinical chemistry values remained in the normal range.
    • The only variable that changed significantly was blood urea nitrogen (a measure of kidney function), which increased significantly after 2 years but not after 1 year in the supplementation groups.
    • Isoflavone supplementation did not affect lymphocyte or serum free thyroxine concentrations.
    • No significant differences in endometrial thickness or fibroids were observed between the groups.
    • 2 serious adverse events were detected (1 case of breast cancer and 1 case of estrogen receptor-negative endometrial cancer), which was less than what was expected for this population of women.

    The bottom line?

    The authors concluded, “Daily supplementation for 2 years with 80 to 120 mg soy hypocotyl isoflavones has minimal risk in healthy menopausal women.”

    12/27/10 21:10 JR

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