The C.A.M. Report
Complementary and Alternative Medicine: Fair, Balanced, and to the Point
  • About this web log

    This blog ran from 2006 to 2016 and was intended as an objective and dispassionate source of information on the latest CAM research. Since my background is in pharmacy and allopathic medicine, I view all CAM as advancing through the development pipeline to eventually become integrated into mainstream medical practice. Some will succeed while others fail. But all are treated fairly here.

  • About the author

    John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at, a complementary and alternative medicine website.

  • Common sense considerations

    The material on this weblog is for informational purposes. It is not medical advice or counsel. Be smart, consult your health professional before using CAM.

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    Vitamin E, selenium, + soy to treat prostate cancer?

    High-grade prostatic intraepithelial neoplasia (HGPIN) is a precursor of invasive prostate cancer (PCa). Some preliminary evidence suggests vitamin E, selenium, and soy protein may prevent progression of HGPIN to PCa.

    Researchers at Princess Margaret Hospital, in Toronto, Ontario tested this hypothesis.

    First, the details.

    • 303 men with biopsy-confirmed HGPIN were randomly assigned to a treatment group for 3 years.
      • Daily soy (40 g), vitamin E (800 U), + selenium (200 ?g)
      • Placebo
    • Follow-up prostate biopsies occurred at 6, 12, 24, and 36 months.
    • The time to development of invasive PCa was recorded.
    • Neither the patients nor researchers knew the treatment given — double blind.

    And, the results.

    • Invasive PCa developed in 26% of patients.
    • The nutritional supplement did not prevent PCa.
    • Gleason score distribution was similar in both groups.
      • Gleason score is a grading system to help evaluate the prognosis of men with prostate cancer.
    • Baseline age, weight, prostate-specific antigen (PSA; a protein produced by the cells of the prostate gland), and testosterone did not predict for development of PCa.
    • The supplement was well tolerated with flatulence reported more frequently (27% v 17%) among men receiving micronutrients.

    The bottom line?

    The authors concluded, “This trial does not support the hypothesis that combination vitamin E, selenium, and soy prevents progression from HGPIN to PCa.”

    Interesting, although an earlier study came to a different conclusion.

    Researchers at the University Hospitals Katholieke Universiteit Leuven, in Belgium, concluded that a 6-month supplementation challenge with selenium, vitamin E, and soy isoflavonoids in men with biopsy-diagnosed isolated HGPIN “predicts for a significantly lower risk of PCa in future biopsies.”

    5/6/11 22:20 JR

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