The C.A.M. Report
Complementary and Alternative Medicine: Fair, Balanced, and to the Point
  • About this web log

    This blog ran from 2006 to 2016 and was intended as an objective and dispassionate source of information on the latest CAM research. Since my background is in pharmacy and allopathic medicine, I view all CAM as advancing through the development pipeline to eventually become integrated into mainstream medical practice. Some will succeed while others fail. But all are treated fairly here.

  • About the author

    John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at, a complementary and alternative medicine website.

  • Common sense considerations

    The material on this weblog is for informational purposes. It is not medical advice or counsel. Be smart, consult your health professional before using CAM.

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  • Recent Comments

    Vitamin D and the risk of dementia

    No prospective study has examined the association between vitamin D and cognitive decline or dementia,… until now.

    Researchers in the US, UK, and Italy studied whether low blood levels of 25-hydroxyvitamin D (25[OH]D) are associated with an increased risk of substantial cognitive decline.

    First, the details.

    • 858 elderly adults completed interviews, cognitive and medical examinations, and provided blood samples.
    • A decline in reasoning (cognition) was assessed using the Mini-Mental State Examination (MMSE).
      • A substantial decline was defined as at least 3 points.
    • The Trail-Making Tests A (using numbers) and B (uses numbers and letters) were used to evaluate visual attention and task switching.
      • A substantial decline was defined as the worst 10% of the distribution of decline or as discontinued testing.

    And, the results.

    • There was substantial cognitive decline in those with severely low 25(OH)D blood levels (less than 25 nmol/L) compared with those who had sufficient levels (greater than 74 nmol/L).
    • The scores of participants who were severely 25(OH)D deficient declined by an additional 0.3 MMSE points per year more than those with sufficient levels of 25(OH)D.
    • The relative risk for substantial decline on Trail-Making Test B (numbers ande letters) was significant, but not with Test A (numbers only).

    The bottom line?

    The authors concluded, “Low levels of vitamin D were associated with substantial cognitive decline in the elderly population studied over a 6-year period, which raises important new possibilities for treatment and prevention.”

    7/16/10 19:43 JR

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