Cholesterol/LipidsFlavonoids (Soy)

Soy fails to improve cholestrol levels

That’s the conclusion from a long-term study by researchers in Florida and Oklahoma.

First, the details.

  • 62 postmenopausal women with moderately high cholesterol levels were randomly assigned to take soy or control foods daily for 1 year.
  • Blood samples were analyzed for total cholesterol, LDL (bad) cholesterol, HDL (good) cholesterol, triglycerides, apolipoprotein (Apo) A, and Apo B.
    • Apolipoproteins bind to fats (Apo A is in LDL cholesterol and Apo B is in HDL cholesterol)

And, the results.

  • There was no change in total cholesterol, triglycerides, and LDL and HDL cholesterol levels after 1 year of soy protein supplementation.
  • There was a significant increase in Apo B levels and a significant decrease in Apo A levels.

The bottom line?

The authors concluded, “1-year soy protein supplementation did not confer cardiovascular benefits, in terms of favorable alterations in the lipid profile.”

A review of 42 studies concluded that soy does have a positive effect on lipids.

The difference might be found in the duration of the studies. The lack of effects after 1 year would seem to be more significant clinically compared to a 12-week study summarized here.

3/11/10 20:56 JR

Hi, I’m JR

John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at, a complementary and alternative medicine website.