The C.A.M. Report
Complementary and Alternative Medicine: Fair, Balanced, and to the Point
  • About this web log

    This blog ran from 2006 to 2016 and was intended as an objective and dispassionate source of information on the latest CAM research. Since my background is in pharmacy and allopathic medicine, I view all CAM as advancing through the development pipeline to eventually become integrated into mainstream medical practice. Some will succeed while others fail. But all are treated fairly here.

  • About the author

    John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at, a complementary and alternative medicine website.

  • Common sense considerations

    The material on this weblog is for informational purposes. It is not medical advice or counsel. Be smart, consult your health professional before using CAM.

  • Recent Posts

  • Recent Comments

    FDA warns against using quinine to treat leg cramps. Options, please?

    The FDA is cracking down on companies that sell quinine-containing products such as Qualaquin for non-approved uses. Their concern is over the risks of quinine to treat leg cramps.

    What’s the risk?
    Although quinine is frequently prescribed for leg cramps, the labeling on Qualaquin (approved to treat malaria) states that side effects include cardiac arrhythmia, low platelet counts, severe hypersensitivity reaction, and death. These risks outweigh “any potential benefit in treating and/or preventing this benign, self-limiting condition [leg cramps],” concludes the FDA.

    Non-drug options
    Here is a review of nocturnal leg cramps in Postgraduate Medicine Online. It recommends several non-drug options that might help.

    Vitamin E has a review of vitamin E.

    A study in 1992 in patients on kidney dialysis who complained of leg cramps concluded that vitamin E was as effective as with quinine. Although the Cochrane Collaboration thinks more research is needed.

    For leg cramps in pregnancy, taking supplements such as magnesium, sodium, or multivitamin/mineral tablets might work, according to the Cochrane Library review. Talk to your doctor before doing any of this.

    Photo: American Osteopathic Association

    12/13/06 10:08 JR

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