The C.A.M. Report
Complementary and Alternative Medicine: Fair, Balanced, and to the Point
  • About this web log

    This blog ran from 2006 to 2016 and was intended as an objective and dispassionate source of information on the latest CAM research. Since my background is in pharmacy and allopathic medicine, I view all CAM as advancing through the development pipeline to eventually become integrated into mainstream medical practice. Some will succeed while others fail. But all are treated fairly here.

  • About the author

    John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at, a complementary and alternative medicine website.

  • Common sense considerations

    The material on this weblog is for informational purposes. It is not medical advice or counsel. Be smart, consult your health professional before using CAM.

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  • Recent Comments

    Effect of proton pump inhibitors on magnesium

    FDA advises that prescription proton pump inhibitor drugs may cause low magnesium blood levels (hypomagnesemia) if taken, in most cases, longer than one year.

    Proton pump inhibitors reduce the amount of acid in the stomach and treat conditions such as gastroesophageal reflux disease (GERD), peptic ulcers, and inflammation of the esophagus.

    • Proton pump inhibitors include:
      • Omeprazole (Prilosec, Zegarid)
      • Lansoprazole (Prevacid)
      • Rabeprazole (Aciphex)
      • Pantoprazole (Protonix)
      • Esomeprazole (Nexium)

    Here’s what we know.

    • Low magnesium levels can result in serious adverse events including muscle spasm (tetany), irregular heartbeat (arrhythmias), and convulsions (seizures).
      • However, patients do not always have these symptoms.
    • Treatment of hypomagnesemia generally requires magnesium supplements.
      • In about one-quarter of cases, magnesium alone did not improve low magnesium levels, and the proton pump inhibitor had to be discontinued.

    The bottom line?

    Healthcare professionals should consider obtaining magnesium blood levels before starting prescription proton pump inhibitor treatment and during chronic treatment.

    Caution in patients who take proton pump inhibitors with medicine such as digoxin, diuretics, or drugs that may cause hypomagnesemia. Low magnesium in a patient taking digoxin increases the risk of serious side effects.

    3/2/11 21:09 JR

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