Anxiety (Panic)/DepressionVitamin DVitamins

Vitamins C, D, and mood disturbance in hospitalized patients

Low blood levels of vitamins C and D are prevalent in acutely hospitalized patients.

Researchers at McGill University, and Jewish General Hospital, in Montreal, Quebec, looked for a change in mood after raising blood levels of these vitamins.

First, the details.

  • 55 patients were assigned to a treatment group.
    • Vitamin C 500 mg twice daily
    • Vitamin D 1000 IU twice daily
  • Changes in mood were assessed using the Profile of Mood States.
  • Neither the patients nor researchers knew the treatment given — double blind.

And, the results.

  • 32 patients completed the study.
  • Vitamin C therapy significantly increased vitamin C levels in blood.
    • This was associated with a significant 34% reduction in mood disturbance.
  • Vitamin D therapy significantly increased 25-hydroxyvitamin D blood concentrations.
    • But this was not accompanied by a significant effect on mood.

The bottom line?

Despite the absence of a placebo control group, the authors concluded, “Treatment of hypovitaminosis C improves the mood state of acutely hospitalized patients.”

10/8/10 20:21 JR

Hi, I’m JR

John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at, a complementary and alternative medicine website.