The C.A.M. Report
Complementary and Alternative Medicine: Fair, Balanced, and to the Point
  • About this web log

    This blog ran from 2006 to 2016 and was intended as an objective and dispassionate source of information on the latest CAM research. Since my background is in pharmacy and allopathic medicine, I view all CAM as advancing through the development pipeline to eventually become integrated into mainstream medical practice. Some will succeed while others fail. But all are treated fairly here.

  • About the author

    John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at, a complementary and alternative medicine website.

  • Common sense considerations

    The material on this weblog is for informational purposes. It is not medical advice or counsel. Be smart, consult your health professional before using CAM.

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    Comparing fructose- and glucose-sweetened beverages

    Overweight and obese subjects consumed glucose- or fructose-sweetened beverages, and researchers from the US and Japan compared the effects.

    A new TV commercial in the US claims there’s no difference. Not so, according to these results. Here are the findings, and the potential significance of this research.

    First, the details.

    • 32 overweight and obese adult men and women were observed for 10 weeks.
    • They drank beverages sweetened with glucose or fructose that accounted for 25% of their daily calorie intake.

    And, the results.

    • Participants in both groups put on about the same amount of weight.
    • Fasting triglyceride blood levels increased 10% with glucose but not with fructose.
    • Changes recorded with fructose only
      • Increased belly fat
      • Production of fat by the liver
        • aka hepatic de novo lipogenesis (DNL)
      • Increased markers of altered lipid metabolism (eg, apoB, LDL [bad] cholesterol)
      • Increased concentrations of remnant-like particle–triglyceride and –cholesterol
        • Newly proposed risk factors for heart disease
      • Increased fasting blood sugar and insulin levels
      • Decreased insulin sensitivity

    The bottom line?
    The authors concluded, “Dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults.”

    An accompanying editorial provides perspective. “While these symptoms are telltale signs of metabolic syndrome, which raises a person’s risk of heart attack, we still don’t know what the long term implications of fructose consumption on such a risk might be.”

    4/23/09 20:30; JR updated 10/10/10 18:47 JR

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