Anxiety (Panic)/DepressionSt. John's Wort

Everything you need to know about St. John’s wort

Dr. Joanne Barnes, from the University of Auckland, in New Zealand distilled the evidence.

And it takes less than 300 words plus references.

Active constituents

  • Probably hypericin, hyperforin, and/or flavonoids

Main use

  • Symptomatic relief of mild to moderately severe depression


  • In 30 studies, more effective than placebo
  • As effective as conventional antidepressants

Side effects

  • Mild gastrointestinal symptoms

Drug interactions

  • Several are listed in the review.

4/27/09 17:56 JR

Hi, I’m JR

John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at, a complementary and alternative medicine website.