The C.A.M. Report
Complementary and Alternative Medicine: Fair, Balanced, and to the Point
  • About this web log

    This blog ran from 2006 to 2016 and was intended as an objective and dispassionate source of information on the latest CAM research. Since my background is in pharmacy and allopathic medicine, I view all CAM as advancing through the development pipeline to eventually become integrated into mainstream medical practice. Some will succeed while others fail. But all are treated fairly here.

  • About the author

    John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at, a complementary and alternative medicine website.

  • Common sense considerations

    The material on this weblog is for informational purposes. It is not medical advice or counsel. Be smart, consult your health professional before using CAM.

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    Negative results giving probiotics in pancreatitis

    In patients predicted to have severe acute pancreatitis, giving probiotics didn’t reduce the risk of infection, according to this study by researchers in the Dutch Acute Pancreatitis Study Group.

    First, the details.

    • 298 patients with predicted severe acute pancreatitis were randomly assigned to receive a multispecies probiotic preparation or placebo within 72 hours of the onset of symptoms.
    • Treatment was twice daily over 28 days.
    • Neither the researchers not the patients knew the treatment given — double-blind.

    And, the results.

    • Infection occurred in 30% patients given the probiotics and in 28% of those given placebo.
    • 16% of patients in the probiotics group died vs 6% in the placebo group — a significant difference.
    • 9 patients in the probiotics group developed bowel ischemia (8 with fatal outcome vs none in the placebo group — a significant difference.

    The bottom line?
    According to the Medscape review of this study, the group getting probiotics was sicker than the placebo group.

    Despite this significant difference in the 2 groups of patients and the effect it might have had on the results, the authors concluded, “Probiotics can no longer be considered to be harmless adjuncts … in critically ill patient.”


    8/30/08 14:00 JR

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