Botulinum toxin type A vs topical creams to treat forehead wrinkles

There’s nothing more complementary than removing a facial wrinkle. Botulinum toxin type A (Botox) is the gold standard for removing glabellar rhytids (forehead winkles). So, it’s not surprising when topical creams sold without a prescription purport to give similar or better outcomes.

Fat chance.

77 women were divided into 5 groups for one of the following treatments.

  • Botulinum toxin type A
  • Placebo injection
  • StriVectin-SD
  • DDF Wrinkle Relax
  • HydroDerm

Using a array of evaluation methods, both the doctors and the women reported significantly better outcomes and satisfaction with Botox.

Now hear this!

  • Treatment with any of the three topical creams did not result in a significant difference from placebo.

What’s more?

  • Three adverse events occurred in three women who received StriVectin-SD.

12/25/06 22:56 JR

Hi, I’m JR

John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at, a complementary and alternative medicine website.