Anxiety (Panic)/DepressionVitamin D

Linking vitamin D and depression

Researchers at The University of Texas Southwestern Medical Center, in Dallas, investigated the association between vitamin D blood levels and depression.

First, the details.

  • 12,594 clinic patients were studied.
  • Blood levels of 25-hydroxyvitamin D [25(OH)D] were analyzed.
  • Depression was defined as a Center for Epidemiologic Studies Depression Scale (CES-D) score of 10 or more.
  • Those with and without a history of depression represented 2 distinct populations with respect to CES-D scores and were analyzed separately.

And, the results.

  • Higher vitamin D levels were associated with a significantly decreased risk of current depression based on CES-D scores.
  • The finding was stronger in those with a prior history of depression and not significant in those without a history of depression.

The bottom line?

The authors concluded, “Low vitamin D levels are associated with depressive symptoms, especially in persons with a history of depression.”

“These findings suggest that primary care patients with a history of depression may be an important target for assessment of vitamin D levels.”

2/14/12 22:02 JR

Hi, I’m JR

John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at, a complementary and alternative medicine website.