Chinese MedicineHerbalsMenopause

Effect of EstroG-100 on menopausal symptoms

Researchers in Korea and the US studied EstroG-100 — a mixture of standardized extracts of Cynanchum wilfordii, Phlomis umbrosa and Angelica gigas.

First, the details.

  • 64 pre-, peri- and postmenopausal White Hispanic, White non-Hispanic, and African American women were randomly assigned to a treatment group for 12?weeks.
    • EstroG-100
    • Placebo group
  • Changes in the Kupperman menopause index (evaluates the severity of menopausal symptoms), and vaginal dryness were measured.
  • Neither the researchers nor patents were aware of the treatment given — double blind.

And, the results.

  • The average Kupperman menopause index score was significantly reduced in the EstroG-100 group (30 to 11) compared with the placebo group (29 to 24) at week 12.
  • Vasomotor symptoms, paresthesia (numbness), insomnia, nervousness, melancholia, vertigo, fatigue, and rheumatic pain were significantly improved in the EstroG-100 group vs the placebo group.
  • Statistically significant improvement in vaginal dryness in the EstroG-100 group was also observed vs the placebo group.

The bottom line?

The authors concluded, “EstroG-100 significantly improved the menopausal symptoms of pre-, peri- and post-menopausal women without weight gain or any serious side effects.”

Cynanchum wilfordii is a perennial herb whose roots have been used in Korea to treat insomnia and anxiety. Phlomis umbrosa purportedly has protective effects on the liver and is used as a haemostatic and to treat athlete’s foot. Angelica gigas is used in Korea to treat “women’s diseases.”

This appears to be the first published study of EstroG.

9/7/11 23:02 JR

Hi, I’m JR

John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at, a complementary and alternative medicine website.