The C.A.M. Report
Complementary and Alternative Medicine: Fair, Balanced, and to the Point
  • About this web log

    This blog ran from 2006 to 2016 and was intended as an objective and dispassionate source of information on the latest CAM research. Since my background is in pharmacy and allopathic medicine, I view all CAM as advancing through the development pipeline to eventually become integrated into mainstream medical practice. Some will succeed while others fail. But all are treated fairly here.

  • About the author

    John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at, a complementary and alternative medicine website.

  • Common sense considerations

    The material on this weblog is for informational purposes. It is not medical advice or counsel. Be smart, consult your health professional before using CAM.

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    Fructose-rich beverages and the risk of gout

    Researchers at Boston University School of Medicine examined the relationship and reported a “modest” increase in risk.

    First, the details.

    • 78,906 women with no history of gout provided information on their intake of beverages using validated food frequency questionnaires.
    • These women were participants in the Nurses’ Health Study, which spanned 22 years (1984-2006).
    • Cases of gout that met the American College of Rheumatology criteria were recorded.

    And, the results.

    • There were 778 cases of gout were reported.
    • Sugar
      • Compared with the drinking less than 1 serving per month of sugar-sweetened soda, drinking 1 or at least 2 servings per day was associated with a significant 1.74- and 2.39-fold increased risk for gout, respectively.
    • Orange juice
      • Drinking orange juice was associated with a significant 1.41- and 2.42-fold increased risk, respectively.
    • Diet drinks
      • Drinking diet soft drinks was not associated with the risk for gout.
    • Fructose
      • Compared with the lowest fructose intake, the risk for gout in women with the highest intake was a significant 1.62.
      • This indicates a risk difference of 28 cases per 100,000 person-years.

    The bottom line?

    The authors concluded, “Consumption of fructose-rich beverages is associated with an increased risk of incident gout, although… the risk of gout … is likely modest given the low incidence rate among women.”

    The overall negative health effect of fructose is expected to be larger in women with a history of gout.

    The authors explain that fructose induces uric acid production by increasing the reaction of adenosine triphosphate (ATP; stores chemical energy) to adenosine monophosphate (AMP), which is precursor to making uric acid.

    11/19/10 19:25 JR

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