Drug interactions with St John’s wort
It’s a long list compiled by researchers at RMIT University in Victoria, Australia.
- Anticancer agents: imatinib (Gleevec) and irinotecan (Camptosar)
- Anti-HIV agents: eg, indinavir (Crixivan), lamivudine (Epivir), and nevirapine (Viramune)
- Anti-inflammatory agents: eg, ibuprofen (Motrin), and fexofenadine (Allegra)
- Antimicrobial agents: eg, erythromycin (Benzamycin), and voriconazole (Vfend)
- Cardiovascular drugs: eg, digoxin (Lanoxin), ivabradine (Procoralan), warfarin (Coumadin), verapamil (Calan), and nifedipine (Procardia), and talinolol
- Central nervous system agents: eg, amitriptyline (Elavil), buspirone, (Buspar), phenytoin (Dilantin), methadone (Dolophine), midazolam (Versed), alprazolam (Xanax), and sertraline (Zoloft)
- Blood sugar lowering drugs: eg, tolbutamide (Diflucan) and gliclazide (Glipizide)
- Immuno-modulating agents: eg, cyclosporine (Sandimmune) and tacrolimus (Prograf)
- Oral contraceptives
- Proton pump inhibitor: eg, omeprazole (Prilosec)
- Respiratory system drugs: eg, theophylline (Theodur)
- Statins: eg, atorvastatin (Lipitor) and pravastatin (Pravachol)
The bottom line?
The article discusses the connection with the CYP enzyme system.
8/30/08 21:57 JR