CAM InteractionsSt. John's Wort

Drug interactions with St John’s wort

It’s a long list compiled by researchers at RMIT University in Victoria, Australia.

  • Anticancer agents: imatinib (Gleevec) and irinotecan (Camptosar)
  • Anti-HIV agents: eg, indinavir (Crixivan), lamivudine (Epivir), and nevirapine (Viramune)
  • Anti-inflammatory agents: eg, ibuprofen (Motrin), and fexofenadine (Allegra)
  • Antimicrobial agents: eg, erythromycin (Benzamycin), and voriconazole (Vfend)
  • Cardiovascular drugs: eg, digoxin (Lanoxin), ivabradine (Procoralan), warfarin (Coumadin), verapamil (Calan), and nifedipine (Procardia), and talinolol
  • Central nervous system agents: eg, amitriptyline (Elavil), buspirone, (Buspar), phenytoin (Dilantin), methadone (Dolophine), midazolam (Versed), alprazolam (Xanax), and sertraline (Zoloft)
  • Blood sugar lowering drugs: eg, tolbutamide (Diflucan) and gliclazide (Glipizide)
  • Immuno-modulating agents: eg, cyclosporine (Sandimmune) and tacrolimus (Prograf)
  • Oral contraceptives
  • Proton pump inhibitor: eg, omeprazole (Prilosec)
  • Respiratory system drugs: eg, theophylline (Theodur)
  • Statins: eg, atorvastatin (Lipitor) and pravastatin (Pravachol)

The bottom line?
The article discusses the connection with the CYP enzyme system.

8/30/08 21:57 JR

Hi, I’m JR

John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at, a complementary and alternative medicine website.