The C.A.M. Report
Complementary and Alternative Medicine: Fair, Balanced, and to the Point
  • About this web log

    This blog ran from 2006 to 2016 and was intended as an objective and dispassionate source of information on the latest CAM research. Since my background is in pharmacy and allopathic medicine, I view all CAM as advancing through the development pipeline to eventually become integrated into mainstream medical practice. Some will succeed while others fail. But all are treated fairly here.

  • About the author

    John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at, a complementary and alternative medicine website.

  • Common sense considerations

    The material on this weblog is for informational purposes. It is not medical advice or counsel. Be smart, consult your health professional before using CAM.

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  • Recent Comments

    Combining psychotherapy with antidepressants for acute major depression

    Combination treatment does not have an advantage over psychotherapy alone, but it’s better than drugs alone, according to this study by researchers in The Netherlands.

    193 patients with major depressive disorder were randomly assigned to 4 treatments for 12 to 16 weeks.

    • Nefazodone (Serzone) plus clinical management
    • Interpersonal psychotherapy (IPT)
    • Nefazodone plus IPT
    • IPT plus placebo
    • In “major depression,” in addition to a depressed mood, the individual suffers from several other typical depressive symptoms that are lasting and disabling.

    And, the results.

    • There were no differences when outcomes were measured using the 17-item Hamilton Rating Scale (HAMD).
    • Based on Montgomery-Asberg Depression Rating Scale (MADRS), nefazodone plus IPT was more effective in reducing depressive symptoms compared to medication alone, but not to psychotherapy alone or IPT plus placebo.

    The bottom line?
    The results of this study support combining medication with psychotherapy instead of using medication only to treat depressed outpatients. Combination treatment did not have an advantage over psychotherapy alone.

    If you’re interested, a brief overview of IPT is here, and a comparison of HAMD and MADRS is here.

    9/9/07 3:27 JR

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