Using fish oil in treating phenylketonuria
Phenylketonuria (PKU) is a genetic disorder that can cause brain damage and mental retardation. Treatment is a low-protein diet.
Now, we learn that fish oil supplementation in children with PKU improved their motor skills (ie, writing, tying shoes, walking and kicking).
First, the details.
- 24 patients older than 4 years of age were evaluated before and after supplementation with fish oil for 3 months (15 mg docosahexaenoic acid [DHA]/kg body weight daily).
- Their response was compared to 22 similar children who did not get the fish oil.
And, the results.
- At the start of the study, patients had low omega-3 fatty acid blood levels, and poor motor skills performance compared to controls.
- Fish oil supplementation increased omega-3 fatty acids and decreased omega-6 fatty acids.
- The patients treated with fish oil also showed improvement in motor skills.
- There were no serious side effects and 8 out of 10 patients reported that omega-3 treatment was well tolerated.
The bottom line?
Dr. Berthold Koletzko and colleagues from the Ludwig-Maximilians-University in Munich, Germany concluded that “Since early and continuously treated patients with PKU benefit from dietary supplementation with n-3 LC-PUFA [omega-3 fatty acids], their addition to the synthetic amino acid mixtures appears advisable.”
More info on PKU is here.
Quiz: Why is the Moby Dick photo used with this post?
7/8/07 14:12 JR