Enriched skim milk powder to prevent gout flares

Laboratory studies have identified two dairy fractions, glycomacropeptide (GMP) and G600 milk fat extract (G600), with anti-inflammatory effects in models of acute gout.

Researchers at the University of Auckland, in New Zealand, tested the concept in humans.

First, the details.

  • 120 patients with recurrent gout flares were randomly assigned to a treatment group for 3 months.
    • Lactose powder control
    • Skim milk powder (SMP) control
    • SMP enriched with GMP and G600 (SMP/GMP/G600)
  • Changes in the frequency of gout flares were recorded.
  • GMP is a carbohydrate-rich casein peptide.

And, the results.

  • The frequency of gout flares was reduced in all groups compared to before the study.
    • There was a significantly greater reduction in gout flares in the SMP/GMP/G600 group vs lactose.
  • Following treatment with SMP/GMP/G600 greater improvements were also observed in pain and fractional excretion of uric acid.
  • There was no significant difference in improvement in tender joint count.
  • Similar adverse event rates and discontinuation rates were observed between the three groups.

The bottom line?

The authors concluded, “In patients with gout… [the findings] suggest that SMP enriched with GMP and G600 may reduce the frequency of gout flares.

The response to treatment with SMP/GMP/G600 might in part be due to G600 inhibition of IL-8 inflammatory activity, which is also inhibited by colchicine — used to treat gout flares.

1/31/12 20:59 JR

Hi, I’m JR

John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at www.Vicus.com, a complementary and alternative medicine website.