5-Loxin is a product made from Boswellia serrata (aka Salai guggal in Ayurvedic medicine).

It has anti-inflammatory action, and was used in this study to treat osteoarthritis of the knee.

First, the details.

  • 75 patients were treated with 100 mg or 250 mg of 5-Loxin daily or placebo.
  • Treatment lasted 90 days.
  • Patients were evaluated for pain and physical function.
  • Additionally, metalloproteinase-3 (a marker for joint inflammation and destruction) was evaluated in synovial (joint) fluid.

And, the results.

  • Both doses of 5-Loxin were associated with clinically and statistically significant improvements in pain and physical function scores.
  • Improvements with 5-Loxin 250 mg were observed 7 days after starting treatment.
  • There was also a significant reduction in synovial fluid matrix metalloproteinase-3.
  • 5-Loxin was well tolerated.

The bottom line?
It’s reported that 5-Loxin is not a COX-2 inhibitor — a form of non-steroidal anti-inflammatory drug (NSAID) that targets COX-2, an enzyme responsible for inflammation and pain. Rather, it’s described as a selective, non-redox inhibitor of the enzyme 5-lipoxygenase.

The authors concluded, “5-Loxin reduces pain and improves physical functioning significantly in osteoarthritis patients; and it is safe for human consumption.”

Yes, the results are encouraging, but any conclusion regarding it’s safety will require more than a 90-day study of 75 patients. I was unable to find published long-term safety data on 5-Loxin, just a rat study.

More background on Boswellia can be found here.

8/1/08 15:09 JR

Hi, I’m JR

John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at www.Vicus.com, a complementary and alternative medicine website.