The C.A.M. Report
Complementary and Alternative Medicine: Fair, Balanced, and to the Point
  • About this web log

    This blog ran from 2006 to 2016 and was intended as an objective and dispassionate source of information on the latest CAM research. Since my background is in pharmacy and allopathic medicine, I view all CAM as advancing through the development pipeline to eventually become integrated into mainstream medical practice. Some will succeed while others fail. But all are treated fairly here.

  • About the author

    John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at, a complementary and alternative medicine website.

  • Common sense considerations

    The material on this weblog is for informational purposes. It is not medical advice or counsel. Be smart, consult your health professional before using CAM.

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    Effect of sublingual cannabinoids on glaucoma

    Six people with early primary open angle glaucoma or ocular hypertension were treated with a single dose of delta-9-tetrahydrocannabinol 5 mg (Delta-9-THC), cannabidiol (CBD) 20 mg and 40 mg, and placebo placed under the tongue on separate occasions.

    Here are the results.

    • At 2 hours, Delta-9-THC significantly lowered intraocular pressure (IOP) vs placebo
    • IOP returned to pretreatment levels by hour 4
    • CBD did not reduce the IOP at any time
    • The higher dose of CBD (40 mg) produced a short-lived increase in IOP by hour 4
    • One patient experienced a transient, mild panic-like reaction after Delta-9-THC administration

    No studies show that marijuana, or any of its components, lower IOP as effectively as drugs already available. In addition, there is the risk of potentially serious side effects, including an increased heart rate and a decrease in blood pressure in studies using smoked marijuana. In this study, one patient out of six had a panic attack.

    9/22/06 20:59 JR

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