The C.A.M. Report
Complementary and Alternative Medicine: Fair, Balanced, and to the Point
  • About this web log

    This blog is intended as an objective and dispassionate source of information on the latest CAM research. Since my background is in pharmacy and allopathic medicine, I view all CAM as advancing through the development pipeline to eventually become integrated into mainstream medical practice. Some will succeed while others fail. But all are treated fairly here.

  • About the author

    John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at www.Vicus.com, a complementary and alternative medicine website.

  • Common sense considerations

    The material on this weblog is for informational purposes. It is not medical advice or counsel. Be smart, consult your health professional before using CAM.

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    Two multivitamin preparations are ineffective for treating biliary atresia

    babyBiliary atresia is a rare disease of infants in which the flow of bile from the liver to the intestine may be blocked and requires surgery. Even after surgery, bile flow may be impaired and lead to a deficiency of fat-soluble vitamins. In this case, vitamin supplements may be needed.

    Researchers from Children’s Hospital Pittsburgh in Pennsylvania studied ADEKs and AquADEKs — products that contain increased amounts of fat-soluble vitamins, which are rapidly absorbed, independent of bile flow.

    First, the details.

    • 57 infants were treated with either corticosteroids or placebo following surgery for biliary atresia.
    • All infants received ADEKs/AquADEKs (2 mL daily) + vitamin K (2.5 mg, 3 times weekly) for 6 months.

    And, the results.

    • 40 of the 57 infants required additional fat-soluble vitamin supplementation to treat a fat-soluble vitamin deficiency.
    • By 6 months the frequency of fat soluble deficiency was
      • Vitamin A deficiency (retinol less than 20 µg/dL) was 27%
      • Vitamin D deficiency (25-OH vitamin D less than 15 ng/mL) was 35%
      • Vitamin E deficiency (α tocopherol less than 3.8 µg/mL) was 5%
      • Vitamin K deficiency (international normalized ratio greater than 1.2) was 21%

    The bottom line?
    “These multivitamin supplements, although theoretically useful, don’t appear to be effective in children whose bilirubin levels are greater than 2,” concluded the authors. “So, one is faced with going back, perhaps, to the method of using multiple individual supplements.”

    Its possible that the dose was too low. Alternatively, perhaps the formulation did not permit adequate availability of fat soluble vitamins to meet the infants’ needs after surgery.

    If the later scenario is the case, this is a good example of the importance of a good pharmaceutical formulation in ensuring that drugs (vitamins) swallowed not only reach the stomach but the rest of the body as well.

    11/4/09 21:40 JR

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